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FIGURE 26.2. Possible mechanisms of regulation of an animal lectin by cognate ligands.


Possible mechanisms of regulation of an animal lectin by cognate ligands. Potential ligands can be on the cell surface and/or on soluble glycoproteins (including sugar chains attached to the lectin itself). As discussed in the text, the “ligand” depicted in this cartoon can either be a simple linear or terminal glycan sequence or a very complex motif that includes more than one monosaccharide and/or additional components. Direct cell–cell interactions could occur among lectin-positive cells (A) or between lectin-positive cells and other cell types bearing cognate ligands (B). Soluble glycoprotein ligands could interact directly with lectin-positive cells (C), bridge between two such cells (D), or inhibit cell–cell interactions involving the lectin (E). Expression of ligands on lectin-positive cells could inactivate the lectin function by either inter- or intramolecular interactions (F).

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From: Chapter 26, Discovery and Classification of Glycan-Binding Proteins

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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