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FIGURE 17.3. Model for glycogen biosynthesis via glycogenin (GN), glycogen synthase (GS), and branching enzyme, as proposed by Carl Smythe and Philip Cohen in the late 1980s.

FIGURE 17.3

Model for glycogen biosynthesis via glycogenin (GN), glycogen synthase (GS), and branching enzyme, as proposed by Carl Smythe and Philip Cohen in the late 1980s. (Step 1) GN is self-priming, attaching glucose to Tyr-194. (Step 2) GN elongates the glucose polymer to contain up to eight monosaccharide units. (Step 3) GS binds. (Step 4) GS elongates the polysaccharide (glycogen) further using the primer produced by GN. (Step 5) Branching enzyme attaches α6 branches to the α4 cores to produce highly branched glycogen polymers.

Symbol Key: FIGURE 17.3. Model for glycogen biosynthesis via glycogenin (GN), glycogen synthase (GS), and branching enzyme, as proposed by Carl Smythe and Philip Cohen in the late 1980s.

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From: Chapter 17, Nucleocytoplasmic Glycosylation

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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