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Guideline: Vitamin A Supplementation in Infants and Children 6–59 Months of Age. Geneva: World Health Organization; 2011.

Cover of Guideline: Vitamin A Supplementation in Infants and Children 6–59 Months of Age

Guideline: Vitamin A Supplementation in Infants and Children 6–59 Months of Age.

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Annex 5Questions in Population, Intervention, Control, Outcomes (PICO) format

Effects and safety of vitamin A supplementation in infants and children 6–59 months of age

  1. Should vitamin A supplements be given to infants and children 6–59 months of age?
  2. If so, at what dose and frequency?
Population:
  • Infants and children 6–59 months of age living in countries where vitamin A deficiency may be of public health concern
  • Subpopulations:

    By child (under 5) mortality rates: countries with low versus high rates

    By interaction with immunization: children receiving vitamin A around the time of measles vaccination versus other times

    By child HIV status: HIV-positive versus HIV-negative versus mixed/unknown

    By exposure to additional vitamin A: children who also received vitamin A supplementation during the first 28 days of life and/or at 1–5 months of age versus those who had not received vitamin A before

Intervention:
  • Any oral vitamin A supplement
  • Subgroup analyses:

    By dose: standard dose (100 000 IU for children 6–11 months of age and 200 000 IU for children 12–59 months of age) versus other doses

    By frequency: every 4–6 months versus other

    By timing: receipt of first dose at 6 months of age versus at 9-month measles contact versus other

Control:Placebo or no treatment
Outcomes:Critical
  • Mortality within the follow-up period:

    Any cause

    Acute respiratory infections

    Diarrhoea

    Measles

  • Hospitalization/clinic visits (number and duration) within the follow-up period:

    Any cause

    Acute respiratory infections

    Diarrhoea

    Adverse effects within 72 hours after receiving supplement

    Vomiting

    Others

Setting:All countries
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Bookshelf ID: NBK185167

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