The figure shows the Risk of bias plot for prognostic surgical studies using the Hayden criteria assessing NT-proBNP. The Y-axis shows 7 specific categories (study participation, study attrition, prognostic factors, outcome measurement, confounding, analysis and study design) used to assess the risk of bias for included studies, while x-axis shows the percentage of 4 possible responses to various questionnaire in each category coded with; yes as dark grey, No as light grey, unclear as white and not applicable as dotted lines. Most studies adequately described the study participants, attrition, prognostic factors, description of statistical analysis and study design. The majority of publications did not adequately describe the outcome measure (item Q4b), and counfounding (items 5a and 5b) was not well addressed by many of the studies.

Figure 16Risk of bias for prognostic surgical studies using the Hayden criteria assessing NT-proBNP

  1. (a) source population clearly defined, (b) study population described (c) study population represents source population, or population of interest
  2. (a) completeness of followup described, (b) completeness of followup adequate
  3. (a) BNP/NTBNP factors defined, (b) BNP/NTBNP factors measured appropriately, (c) Other factors measured appropriately, (d) For BNP/NTBNP, the extent of and reasons for indeterminate test results or missing data reported, (e) for other prognostic factors, the extent of and reasons for indeterminate test results or missing data reported
  4. (a) outcome defined, (b) outcome measured appropriately, (c) a composite outcome was avoided
  5. (a) confounders measured, (b) confounders accounted for
  6. (a) analysis described;
  7. (a) The study was designed to test the prognostic value of BNP/NT-proBNP

From: Results

Cover of Use of Natriuretic Peptide Measurement in the Management of Heart Failure
Use of Natriuretic Peptide Measurement in the Management of Heart Failure [Internet].
Comparative Effectiveness Reviews, No. 126.
Balion C, Don-Wauchope A, Hill S, et al.

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