Table 12Summary of the wound healing measures* among patients with chronic venous ulcers comparing biological or cellular dressings with compression alone

Author, YearIntervention, NCompression Used in Both GroupsFollowup TimeProportion Of Ulcers Healed, N / N (%)Wound Healing RateWound Recurrence
Krishnamoorthy, 200347G1: Cellular skin substitute or ECM Dermagraft 12 pcs
G2: Cellular skin substitute or ECM Dermagraft 4pc
G3: Cellular skin substitute or ECM Dermagraft 1pc
G4: Compression only
Multilayer Profore12 weeksG1: 5 / 13 (38)
G2: 5 / 13 (38)
G3: 1 / 13 (8)
G4: 2 / 13 (15); P>0.05
NRNR
Omar, 200434G1: Compression only
G2: human fibroblast derived dermal replacement, Dermagraft®
4-layer12 weeksNRG1: 0.15 cm2 per week
G2: 0.82 cm2 per week; P = 0.001
NR
Falanga, 1998 38G1: Compression, 129
G2: Cellular skin substitute or ECM, 146
Unna boot6 monthsG1: 63 / 129 patients (49)
G2: 92 / 146 patients (63); P=0.02
G1: Median days, 181 (Range, 10 to 232)
G2: Median days, 61 (Range, 9 to 233)
RH of wound closure per unit time, 1.5 (CI, 1.3 to 1.9)
G1: 10 / 63 (16)
G2: 11 / 92 (12); P=0.48
Vanscheidt, 200726G1: Contact layer, 109
G2: Contact layer + cellular skin substitute or ECM, 116
Short stretch182 daysG1: 24 / 109 patients (22)
G2: 44 / 116 patients (38); P=0.0106
G1: Median days, > 201 (CI, 201 to ∞)
G2: Median days, 176 (CI, 114 to 184); P < 0.0001
NR
Falanga,199951

[Subgroup analysis from Falanga, 199838 on ulcers > 1 year duration]
G1: Compression
G2: Cellular skin substitute or ECM
Unna boot24 weeksG1: 9 / 48 (19)
G2: 34 / 72 (47) P<0.005
G1: closure not attained
G2: 181 days (P<0.005)
G1: 4 / 54 (7) at 6 months
12 / 54 (22) at 12 months
G2: 6 / 72 (8) at 6 months
13 / 72 (18) at 12 months
*

None of the studies reported on time-to-healing.

CI = 95% confidence interval; cm = centimeter; ECM = extracellular matrix; G = group; NR = not reported; RH = relative hazard

None of the studies reported on time-to-healing.

From: Results

Cover of Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities
Chronic Venous Ulcers: A Comparative Effectiveness Review of Treatment Modalities [Internet].
Comparative Effectiveness Reviews, No. 127.
Zenilman J, Valle MF, Malas MB, et al.

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