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McIntosh B, Clark M, Spry C. Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2011 Jan.

Cover of Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines

Benzodiazepines in Older Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines [Internet].

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APPENDIX 1LITERATURE SEARCH STRATEGY

OVERVIEW
Interface:Ovid
Databases:BIOSIS Previews <1989 to 2010 Week 36>
EMBASE <1996 to 2010 Week 32>
Ovid MEDLINE <1950 to Present (24 Aug 2010)>
Ovid MEDLINE In-Process & Other Non-Indexed Citations
Note: Subject headings have been customized for each database. Duplicates between databases were removed in Ovid.
Date of Search:August 24, 2010
Alerts:Monthly search updates began August 24, 2010 and ran until October 4, 2010.
Study Types:Systematic reviews; meta-analyses; technology assessments; randomized controlled trials; economic studies; guidelines.
Limits:Publication years January 1, 2005 – August 24, 2010, English language
SYNTAX GUIDE
/At the end of a phrase, searches the phrase as a subject heading
expExplode a subject heading
*Before a word, indicates that the marked subject heading is a primary topic; or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying endings
ADJRequires words are adjacent to each other (in any order)
ADJ#Adjacency within # number of words (in any order)
.tiTitle
.abAbstract
.hwHeading Word; usually includes subject headings and controlled vocabulary
.mp.Mapped Word
.jw.Journal Word
.md.Methodology field
.ptPublication type
.rnCAS registry number
use prmzSelect MEDLINE results
use emefSelect EMBASE results
use b10o89Select BIOSIS results
MULTI-DATABASE STRATEGY
Line #Search Strategy
1exp Benzodiazepines/ or (benzodiazepine* or Alprazolam or Bromazepam or Chlordiazepoxide or Clobazam or Clonazepam or Clorazepate or Diazepam or Flurazepam or Lorazepam or Midazolam or Nitrazepam or Oxazepam or Temazepam or Triazolam or ativan or xanax or lectopam or rivotril or valium or anexate or dalmane or mogadon or restoril or librax or nitrazadon or diazemuls or BZD).ti,ab. or (12794-10-4 or 28981-97-7 or 1812-30-2 or 58-25-3 or 58-25-3 or 22316-47-8 or 1622-61-3 or 57109-90-7 or 439-14-5 or 17617-23-1 or 846-49-1 or 59467-70-8 or 146-22-5 or 604-75-1 or 846-50-4 or 28911-01-5).rn.
2*benzodiazepine/ or *bromazepam/ or *chlordiazepoxide/ or *clobazam/ or *clonazepam/ or *clorazepate dipotassium/ or *diazepam/ or *flurazepam/ or *lorazepam/ or *nitrazepam/ or *oxazepam/ or *temazepam/
3exp Aged/ or geriatrics/ or (elderly or elder or elders or aging or older adult* or older people or older patient* or older person* or older women or older men or older individual* or geriatric* or gerontology or senior citizen or senior citizens or seniors or septuagenarian* or octogenarian* or nonagenarian*).ti,ab.
4(elderly or elder or elders or aging or older adult* or older people or older patient* or older person* or older women or older men or older individual* or geriatric* or senior citizen or senior citizens or seniors or septuagenarian* or octogenarian* or nonagenarian*).ti,ab.
51 and 3
6limit 5 to english language
7limit 6 to yr="2005 -Current"
87 use prmz
91 and 4
109
11limit 10 to english language
12limit 11 to yr="2005 -Current"
13[12 use b10o89]
142 and 3
15limit 14 to english language
16limit 15 to yr="2005 -Current"
17[16 use emef]
188 or 13 or 17
19remove duplicates from 18
Systematic review / health technology assessment / meta-analysis filter
20meta-analysis.pt.
21meta-analysis/ or systematic review/ or meta-analysis as topic/ or exp technology assessment, biomedical/
22((systematic* adj3 (review* or overview*)) or (methodologic* adj3 (review* or overview*))).ti,ab.
23((quantitative adj3 (review* or overview* or synthes*)) or (research adj3 (integrati* or overview*))).ti,ab.
24((integrative adj3 (review* or overview*)) or (collaborative adj3 (review* or overview*)) or (pool* adj3 analy*)).ti,ab.
25(data synthes* or data extraction* or data abstraction*).ti,ab.
26(handsearch* or hand search*).ti,ab.
27(mantel haenszel or peto or der simonian or dersimonian or fixed effect* or latin square*).ti,ab.
28(met analy* or metanaly* or health technology assessment* or HTA or HTAs).ti,ab.
29(meta regression* or metaregression* or mega regression*).ti,ab.
30(meta-analy* or metaanaly* or systematic review* or biomedical technology assessment* or bio-medical technology assessment*).mp,hw.
31(medline or Cochrane or pubmed or medlars).ti,ab,hw.
32(cochrane or health technology assessment or evidence report).jw.
33(meta-analysis or systematic review).md.
34or/20–33
Economic filter
35*Economics/
36exp "Costs and Cost Analysis"/
37(sensitivity analysis or sensitivity analyses).ti,ab.
38(cost or costs or costing or cost-effective$).ti,ab.
39or/35–38
Guideline filter
40exp clinical pathway/
41exp clinical protocol/
42exp consensus/
43exp consensus development conference/
44exp consensus development conferences as topic/
45critical pathways/
46exp guideline/
47guidelines as topic/
48exp practice guideline/
49practice guidelines as topic/
50health planning guidelines/
51exp treatment guidelines/
52(guideline or practice guideline or consensus development conference or consensus development conference, NIH).pt.
53(position statement* or policy statement* or practice parameter* or best practice*).ti,ab.
54(standards or guideline or guidelines).ti.
55((practice or treatment*) adj guideline*).ab.
56(CPG or CPGs).ti.
57consensus*.ti.
58consensus*.ab. /freq=2
59((critical or clinical or practice) adj2 (path or paths or pathway or pathways or protocol*)).ti,ab.
60recommendat*.ti.
61(care adj2 (standard or path or paths or pathway or pathways or map or maps or plan or plans)).ti,ab.
62(algorithm* adj2 (screening or examination or test or tested or testing or assessment* or diagnosis or diagnoses or diagnosed or diagnosing)).ti,ab.
63(algorithm* adj2 (pharmacotherap* or chemotherap* or chemotreatment* or therap* or treatment* or intervention*)).ti,ab.
64or/40–63
Randomized controlled trial filter
65Randomized Controlled Trial.pt.
66Randomized Controlled Trials as Topic/
67Randomized Controlled Trial/
68Randomization/
69Random Allocation/
70Double-Blind Method/
71Double Blind Procedure/
72Double-Blind Studies/
73Single-Blind Method/
74Single Blind Procedure/
75Single-Blind Studies/
76Placebos/
77Placebo/
78(random* or sham or placebo*).ti,ab,hw.
79((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
80((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw.
81or/65–80
8219 and (34 or 39 or 64 or 81)
OTHER DATABASES
PubMedSame MeSH, keywords, limits, and study types used as per MEDLINE search, with appropriate syntax used.
The Cochrane Library
Issue 8, 2010
Same MeSH, keywords, and date limits used as per MEDLINE search, excluding study types. Syntax adjusted for Cochrane Library databases.

Grey Literature

Dates for Search:August 16, 2010 – August 26, 2010
Keywords:benzodiazepine, elderly, drug names for benzodiazepines produced by Canadian manufacturers
Limits:Publication years January 1, 2005 – August 26, 2010

The following sections of the CADTH grey literature checklist, Grey matters: a practical tool for evidence-based searching (http://www.cadth.ca/index.php/en/cadth/products/grey-matters) were searched:

  • Health Technology Assessment Agencies
  • Health Economic
  • Clinical Practice Guidelines
  • Databases (free)
  • Internet Search
  • Open Access Journals
Copyright © CADTH (January 2011)

You are permitted to make copies of this document for non-commercial purposes provided it is not modified when reproduced and appropriate credit is given to CADTH.

Links: This document may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third-party sites is governed by the owners’ own terms and conditions set out for such sites. CADTH does not make any guarantee with respect to any information contained on such third-party sites and CADTH is not responsible for any injury, loss, or damage suffered as a result of using such third-party sites.

Industry: The following manufacturers were provided with an opportunity to comment on an earlier version of this report: Sepracor Pharmaceuticals Inc., Hoffmann-La Roche Ltd., and Pfizer Canada Inc. All comments that were received were considered when preparing the final report.

Bookshelf ID: NBK174559
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