Figure 3.. The chromosomal instability pathway of tumorigenesis.

Figure 3.

The chromosomal instability pathway of tumorigenesis. As tumors progress down the chromosomal instability (CIN) pathway from early stage adenomas to carcinomas, they acquire somatic mutations that result in aberrant Wnt signaling. Accumulation of mutations leads to invasion, malignancy, regional lymph node metastasis, and distant metastasis, primarily in the liver and lungs. Epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are thought to contribute to local invasion and metastasis, respectively. Figure adapted from John Hopkins Medicine, 2010.177

From: MicroRNAs and the Progression of Colorectal Cancer

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