Fig. 4. Processes of hepatic IFN production from exogenous sources.

Fig. 4

Processes of hepatic IFN production from exogenous sources. Various processes can result in hepatic ISG expression despite a block to the host response imposed by the actions of HCV proteins. In most of the examples shown, IFN will be produced from non-infected (exogenous) cell sources and not from the chronic HCV-infected hepatocyte, which studies have shown do not express appreciable levels of IFN (Mihm et al., 2004). NS5A triggering of STAT3 signaling (Waris et al., 2005) would produce ISGs in the absence of IFN, and this affect would be limited to infected cells.

From: Chapter 13, HCV Regulation of Host Defense

Cover of Hepatitis C Viruses
Hepatitis C Viruses: Genomes and Molecular Biology.
Tan SL, editor.
Norfolk (UK): Horizon Bioscience; 2006.
Copyright © 2006, Horizon Bioscience.

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