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Cover of Hepatitis C Viruses

Hepatitis C Viruses

Genomes and Molecular Biology

Edited by Seng-Lai Tan, PhD.

Lilly Research Laboratories, Indianapolis, USA
Norfolk (UK): Horizon Bioscience; .
ISBN-10: 1-904933-20-3ISBN-13: 978-1-904933-20-5

Excerpt

Chronic hepatitis C is a serious public health problem and a disease burden in many parts of the world. The discovery of the causative agent, hepatitis C virus (HCV), in 1989 has initiated an almost unparalleled research activity in academic and pharmaceutical-industry laboratories over the ensuing years. This book aims to provide a state-of-the-art account of recent advances in the molecular and cellular biology, immunology and pathogenesis of HCV. It also aspires to discuss new strategies as well as outstanding issues for future research.

Hepatitis C has been dubbed the “silent epidemic” because it is generally asymptomatic for decades after infection; its victims often are unaware of the infection until it is too late for therapy. What is the genetic makeup and molecular features that make HCV such a “silent” yet deadly assassin? This question, in fact, is the premise by which this monograph was prepared – it was an attempt to decode the secrets of HCV, one viral gene at a time. To that end, we assembled a team of highly regarded experts from different disciplines who have prepared 16 chapters on various aspects of HCV, including the HCV genome and the role(s) of each viral gene product within the context of the viral life cycle, host interactions, and regulation of host antiviral defense and adaptive immunity.

Contents

Copyright © 2006, Horizon Bioscience.
Bookshelf ID: NBK1613PMID: 21250377
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