Figure 7.3. Ratio of incidence rates between normal and mutant genotypes when there is a single line of progression, L = 1.

Figure 7.3

Ratio of incidence rates between normal and mutant genotypes when there is a single line of progression, L = 1. The normal genotype has n steps in progression to cancer; the mutant has nj steps. The top row shows the ratio on a log10 scale, calculated from Eq. (7.3). The bottom row shows the slope of the top plots, calculated from Eq. (7.4). The values of j are 1 (solid lines), 2 (long-dash lines), 3 (short-dash lines), and 4 (dot-dash lines). The total incidence for the normal genotype was set to 0.1, which required u = 0.0304 for n = 5, and u = 0.0778 for n = 10.

From: Chapter 7, Theory II

Cover of Dynamics of Cancer
Dynamics of Cancer: Incidence, Inheritance, and Evolution.
Frank SA.
Princeton (NJ): Princeton University Press; 2007.
Copyright © 2007, Steven A Frank.

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