Figure 5.2. Multistage model of cancer progression.

Figure 5.2

Multistage model of cancer progression. Individuals are born in stage 0. They progress from stage 0 through the first transition to stage 1 at a rate u0, then to stage 2 at a rate u1, and so on. Severe cancer only arises after transition to the final stage. With regard to epidemiology, the rate at which individuals enter the final stage, n = 6 in this case, is approximately proportional to tn−1 as long as cancer remains rare and the ui's are not too different from each other.

From: Chapter 5, Progression Dynamics

Cover of Dynamics of Cancer
Dynamics of Cancer: Incidence, Inheritance, and Evolution.
Frank SA.
Princeton (NJ): Princeton University Press; 2007.
Copyright © 2007, Steven A Frank.

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