Figure 9.6. Consequences of heterogeneity in individual susceptibility on carcinogen dose-response curves.

Figure 9.6

Consequences of heterogeneity in individual susceptibility on carcinogen dose-response curves. All curves derive from the response function shown in Figure 9.5a: in panels (a) and (b), the average value of susceptibility is b̄ = 0.05; in panels (c) and (d), the average is b̄ = 0.025. Panels (a) and (c) show the dose-response curves when averaged over heterogeneity in susceptibility, calculated from Eq. (9.5). The three curves in each panel correspond to the three distributions of susceptibility, b, in Figure 9.4. Panels (b) and (d) show the corresponding log-log slopes of the dose-response curves, calculated from Eq. (9.6).

From: Chapter 9, Carcinogens

Cover of Dynamics of Cancer
Dynamics of Cancer: Incidence, Inheritance, and Evolution.
Frank SA.
Princeton (NJ): Princeton University Press; 2007.
Copyright © 2007, Steven A Frank.

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