Figure 2.. Routes of metastasis.

Figure 2.

Routes of metastasis. Cancer cells (blue) can utilize the circulation system as well as lymph nodes to reach a distant organ and form a metastasis. The two routes, lymphatic route (red arrows) and hematogenous route (blue arrows), are depicted above. Adapted with permission from Macmillan Publishers Ltd. Nature Reviews Cancer. Pantel K, Brakenhoff, RH, Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4(6):448-56; Copyright 2004.

From: Metastatic Breast Cancer to the Brain: A Clinical Primer for Translational Investigation

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