Table 10Overview of included randomized controlled trials

Treatment Comparison DateN/nOutcomesDrugs Studied% Industry Funded% Good Quality% Fair Quality% Poor Quality
Oral S vs. Oral nS
1987-1996
381-83/515Nasal, QoL, AECetirizine, loratadine
Clemastine, chlorpheniramine
3303367
Oral S vs. Nasal AH
1993-2006
584-88/1052Nasal, QoL, AECetirizine, desloratadine, loratadine
Azelastine
4040060
Oral S vs. INCS
1995-2009
1389-100/4403Nasal, Eye, QoL, AECetirizine, fexofenadine, loratadine
Beclomethasone, fluticasone furoate, fluticasone propionate, mometasone, triamcinolone
92152362
Oral S vs. Oral D
1995-2009
7101-107/3595Nasal, Eye, QoL, AECetirizine, desloratadine, fexofenadine, loratadine
Pseudoephedrine
71431443
Oral S vs. Oral LRA
2000-2009
997, 108-114/4404Nasal, Eye, Asthma, QoL, AEDesloratadine, levocetirizine, loratadine
Montelukast
78332245
INCS vs. Nasal AH
1995-2012
9115-121/3527Nasal, Eye, QoL, AEBeclomethasone, fluticasone propionate
Azelastine, olopatadine
6756044
INCS vs. Nasal C
1985-2005
4122-125/436Nasal, QoL, AEBeclomethasone, budesonide, flunisolide, fluticasone propionate, mometasone,
Cromolyn
7500100
INCS vs. Oral LRA
2002-2009
597, 126-129/2444Nasal, Asthma, QoL, AEBeclomethasone, fluticasone propionate
Montelukast
10060040
Oral S + INCS vs. Oral S
1998-2008
390, 98, 130/677Nasal, Eye, QoL, AECetirizine, loratadine
Mometasone, fluticasone propionate
3306733
Oral S + INCS vs. INCS
1994-2008
562, 90, 98, 131, 132/1170Nasal, Eye, QoL, AECetirizine, levocetirizine, loratadine
Fluticasone propionate, mometasone
40202060
INCS + Nasal AH vs. INCS
2008-2012
5115, 117, 121/3151Nasal, Eye QoL, AEAzelastine
Fluticasone propionate
10010000
INCS + Nasal AH vs. Nasal AH
2008-2012
5115, 117, 121/3151Nasal, Eye QoL, AEAzelastine
Fluticasone propionate
10010000
Oral S + Oral D vs. Oral S
1995-2009
7101-107/3575Nasal, Eye QoL, AECetirizine, desloratadine, fexofenadine, loratadine
Pseudoephedrine
71431443
Pedi Oral S vs. Oral nS
1989-1996
2133, 134/166Nasal, Eye QoL, AECetirizine, loratadine
Chlorpheniramine, dexchlorpheniramine
5005050

Note: N/n=number of trials/number of patients in treatment arms of interest. Date is the range of publication dates.

AC = anticholinergic; AE = adverse events; C = cromolyn; INCS = intranasal corticosteroid; LRA = leukotriene receptor antagonist; NS = nasal saline; nS = nonselective antihistamine; QoL= quality of life; RCT = randomized controlled trial; S = selective antihistamine; D = sympathomimetic decongestant.

From: Results

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.