Appendix Table C82Comparative harms: combination intranasal corticosteroid plus nasal antihistamine versus nasal antihistamine

Author, YearDrug, Dose/DayN/nSedationHeadacheNasal DiscomfortBitter AftertasteNosebleeds
Carr, 2012 (Trial 1)Azelastine 548 mcg/Fluticasone propionate 200 mcg207/2070.512.41
Azelastine 548 mcg208/2080.
Carr, 2012 (Trial 2)Azelastine 548 mcg/Fluticasone propionate 200 mcg193/1932.
Azelastine 548 mcg194/1942.117.21.6
Carr, 2012 (Trial 3)Azelastine 548 mcg/Fluticasone propionate 200 mcg448/4481.
Azelastine 548 mcg445/4450.425.11.1
Hampel, 2010Azelastine 548 mcg/Fluticasone propionate 200 mcg153/1530.
Azelastine 548 mcg152/1520.71.3022.6
Ratner, 2008aAzelastine 8 puffs/Fluticasone propionate 200 mcg52/525.813.5
Azelastine 8 puffs49/494.18.2

N/n = Number of patients randomized/number of patients analyzed.

Symptom severity is unspecified unless otherwise noted (MILD, MOD = moderate, or SEV = severe).


Sample of reports.

From: Appendix C, Evidence Tables

Cover of Treatments for Seasonal Allergic Rhinitis
Treatments for Seasonal Allergic Rhinitis [Internet].
Comparative Effectiveness Reviews, No. 120.
Glacy J, Putnam K, Godfrey S, et al.

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