Table 3-8Parameters Used in the Sweeney et al. (2008) PBPK Model for 1,4-Dioxane

RatsMiceHumans
Body weight (kg)       0.25       0.025     70.0
Percentage of body weight
   Liver       3.4       5.5       3.3
   Fat       7.0       7.0     21.4
   Rapidly perfused1 - (sum of other tissue volumes)
   Slowly perfused     59.4     54.9     43.7
   Blood       7.4       4.9       7.9
   Unperfused tissue       5.0       5.4       7.1
Flows (L/hour/kg0.74)
   Alveolar ventilation     13     20     13
   Cardiac output     13     20     13
Percent of cardiac output
   Liver     18.3     16.1     22.7
   Fat       7.0       7.0       5.2
   Rapidly perfused1 - (flow to liver, fat, and slowly perfused)
   Slowly perfused     33.6     21.7     24.9
Partition coefficients
   Blood/air1,8612,0021,666
   Liver/air1,8621,1431,500
   Fat/air   851   879   865
   Rapidly perfused/air   560   560   560
   Slowly perfused/air1,3411,7051,503
   Saline/air2,4462,4462,446
Metabolic constants (allometric)
   Vmaxc (mg/hour/kg0.74)a    7.5 or 12.7     39 or 46  54, 75, or 192
Km (mg/L)a     21     21  29, 32, or 47
Miscellaneous constants
Ka (hour−1)a       0.8       0.8Not derived
Kme (hour −1)a       0.48       0.35       0.35
Metabolite volume of distribution (L/kg)       1.0       0.83       0.83
a

Values obtained by model optimization.

Source: Adapted from Sweeney et al. (2008)

Values obtained by model optimization.

From: 3, HEALTH EFFECTS

Cover of Toxicological Profile for 1,4-Dioxane
Toxicological Profile for 1,4-Dioxane.
Wilbur S, Jones D, Risher JF, et al.

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