Figure A depicts the key questions (KQs) within the context of the PICO (population, interventions, comparators, and outcomes) described elsewhere in this document. In general, the figure shows that the CER will consider the accuracy of one noninvasive diagnostic test (NIT) vs. another or vs. coronary angiography for diagnosing obstructive and nonobstructive coronary artery disease (CAD) in women with symptoms suspicious for CAD (KQ 1, encompassing evidence gaps #1-#8); various possible predictors of diagnostic accuracy (including age, race/ethnicity, body size, heart size, menopausal status, functional status, and stress modality) of the different NITs in this context (KQ 2); whether the use of NITs improves prognostic information, risk stratification, treatment offered, and clinical outcomes (including myocardial infarction, unstable angina, hospitalization, death, revascularization, angina relief, and quality of life in the population of interest) (KQ 3 and evidence gap #10); and whether there are significant safety concerns or risks (including radiation exposure, access site complications, contrast agent-induced nephropathy, nephrogenic systemic fibrosis, anaphylaxis, and arrhythmias) associated with the use of NITs in this context (KQ 4 and evidence gap #9).

Figure AAnalytic framework

CAD = coronary artery disease; KQ = Key Question; NSF = nephrogenic systemic fibrosis

Note: #1 to #10 represent the evidence gaps outlined in Table A.

From: Executive Summary

Cover of Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women: Future Research Needs
Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 58 [Internet].
Future Research Needs Papers, No. 41.
Sanders GD, Patel MR, Chatterjee R, et al.

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