Table 1Active heterocyclic biaryl analogs

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SIDYRhM5 EC50 (μM)AChmax (%)
137294170CHBr> 1067
137294173CHOMe> 1072
137294176NSMe> 1060
137294177NOMe> 1074

From: Development and characterization of a highly selective M5 PAM probe molecule with improved potency

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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