Figure 8. A) Intracellular ROS levels measured with increasing concentrations of H2O2 in either DMSO or ML285 treated A549 cells.

Figure 8

A) Intracellular ROS levels measured with increasing concentrations of H2O2 in either DMSO or ML285 treated A549 cells. B) ROS concentration measured in MEF cell lines expressing either PKM2 or PKM1 with and without H2O2 treatment. C) Cell survival measured in both DMSO and ML285 treated cells with and without diamide treatment. D) Cell survival measure in WT and C358S mutant cells with and without diamide treatment.

From: ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2

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