Table 24Endovascular versus surgical revascularization: lower extremity amputation

Study PopulationType of Study
N Analyzeda
Quality
Outcome
Length of Followup
Results Reported by Authors
Patients with CLI
Adam, 200539

BASIL Study

Patients with CLI
RCT
N: 452
Good
Amputation

6 mo
1 yr
3 yr
6 mo
Endovascular: 4.5%
Surgical: 2.6%

1 yr
Endovascular: 14.7%
Surgical: 12.3%

3 yr
Endovascular: 19.2%
Surgical: 18.9%
Ah Chong, 2009100

Patients with CLI
Observational
N: 464
Poor
Limb salvage

1 yr
3 yr
5 yr
1 yr
Endovascular: 93%
Surgical: 82%

3 yr
Endovascular: 89%
Surgical: 78%

5 yr
Endovascular: 77%
Surgical: 76%
Dorigo, 2009101

Patients with CLI
Observational
N: 73
Fair
Limb salvage

1 yr
Endovascular: 96.8%
Surgical: 88.2%
Dosluoglu 2012119

Patients with CLI
Observational
N: 433
Fair
Limb salvage

5 yr
Endovascular: 78%
Surgical: 78%
Faglia, 2012118

Patients with CLI
Observational
N: 332
Fair
Major amputation

30 days
18 mo
30 days
Endovascular: 2.7%
Surgical: 7.5%

18 mo
Endovascular: 7.5%
Surgical: 20%
Hynes, 2004102

Patients with CLI
Observational
N: 137
Fair
Limb salvage

1 yr
Femoropopliteal disease (N=102)
Endovascular: 97%
Surgical: 82%

Aortoiliac disease (N=35)
Endovascular: 100%
Surgical:86%
Korhonen, 2011105

Patients with CLI
Observational
N: 858
Good
Limb salvage

1 yr
3 yr
5 yr
1 yr
Endovascular: 87%
Surgical: 95%

3 yr
Endovascular: 77.0%
Surgical: 79.3%

5 yr
Endovascular: 75.3%
Surgical: 76.0%
Kudo, 2006106

Patients with CLI
Observational
N: 192 (237 limbs)
Poor
Limb salvage

5 yr
Endovascular: 91%
Surgical: 77%
Loor, 2009108

Patients with CLI
Observational
N: 92
Fair
Limb salvage

1 yr
Endovascular: 87%
Surgical: 69%
Soderstrom, 2010110

Patients with CLI
Observational
N: 1023
Fair
Limb salvage

1 yr
3 yr
5 yr
1 yr
Endovascular: 85.5%
Surgical: 82.2%

3 yr
Endovascular: 77.0%
Surgical: 79.3%

5 yr
Endovascular: 75.3%
Surgical: 76.0%
Sultan, 2009109

Patients with CLI
Observational
N: 309
Fair
Major amputation

5 yr
Endovascular: 27.1%
Surgical: 28.8%
Taylor, 2005112Observational
N: 122
Fair
Limb salvage

2-3 yr
Endovascular: 74.3%
Surgical: 82.5%
Taylor, 2006111

Patients with CLI
Observational
N: 841
Poor
Limb Salvage

1 yr
Endovascular: 76.5%
Surgical: 82.4%
Varela, 2011114

Patients with CLI
Observational
N: 88 (91 limbs)
Fair
Limb salvage

2 yr
Endovascular: 83%
Surgical: 72%
Varty, 199699

Patients with CLI
Observational
N: 188
Fair
Limb salvage

1 yr
1 yr
Endovascular: 76%
Surgical: 76%
Venermo, 2011115

Patients with CLI
Observational
N: 597
Poor
Limb salvage

1 yr
Endovascular: 88.3%
Surgical: 84.9%
Wolfle, 2000116

Patients with CLI
Observational
N: 209
Poor
Limb salvage

1 yr
6 yr
1 yr
Endovascular: 82%
Surgical: 80%

6 yr
Endovascular: 63%
Surgical: 69%
Patients with IC or CLI
Dosluoglu, 201038

Patients with IC or CLI
Observational
IC: 38% in endovascular arm, 25% in surgical and hybrid arms
CLI: 62% in endovascular arm, 75% in surgical and hybrid arms
N: 654
Poor
Amputation

30 days

Limb salvage

1 yr
3 yr
30 days
Endovascular: 2.1%
Surgical: 1.8%

1 yr
Endovascular: 86%
Surgical: 80%

3 yr
Endovascular: 80%
Surgical: 74%
Kashyap, 2008131

Patients with IC or CLI
Observational
IC: 54% in endovascular arm, 51% in surgical arm
CLI: 46% in endovascular arm, 49% in surgical arm
N: 169
Fair
Amputation

1 yr
2 yr
3 yr
1 yr
Endovascular: 2%
Surgical: 2%

2 yr
Endovascular: 2%
Surgical: 2%

3yr
Endovascular: 2%
Surgical: 2%
Lepantalo, 2009123

Patients with IC or CLI
RCT
IC: 87% in endovascular arm, 90% in surgical arm
CLI: 13% in endovascular arm, 10% in surgical arm
N: 44
Fair
Amputation

18 mo
Endovascular: 0%
Surgical: 4.8%
McQuade, 2009124

Patients with IC or CLI
RCT
IC: 82% in endovascular arm, 62% in surgical arm
CLI: 18% in endovascular arm, 38% in surgical arm
N: 86
Fair
Amputation

18 mo
2 yr
4 yr
18 mo
Endovascular: 3.1%
Surgical: 13.5%

2 yr
Endovascular: 2.6%
Surgical: 12.5%

4 yr
Endovascular: 3.1%
Surgical: 23.1%
a

Number of patients in the study arms of interest.

Abbreviations: CLI=critical limb ischemia; IC=intermittent claudication; mo=month/months; yr=year/years.

Number of patients in the study arms of interest.

From: Results

Cover of Treatment Strategies for Patients With Peripheral Artery Disease
Treatment Strategies for Patients With Peripheral Artery Disease [Internet].
Comparative Effectiveness Reviews, No. 118.
Jones WS, Schmit KM, Vemulapalli S, et al.

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