This figure shows the forest plot of the hazard ratio for the three RCTs that reported nonfatal MI events. The Belch, 2008 (POPADAD) study and the Fowkes, 2010 study both looked at asymptomatic PAD patients and had total Ns of 636 and 3350 respectively. The Catalano, 2007 (CLIPS) study looked at IC patients and had a total N of 181. The result was an estimated hazard ratio of 0.98 (95% CI, 0.68 to 1.42, p=0.92) favoring aspirin for the Belch study. The estimated hazard ratio for the Fowkes study was 0.91 (CI, 0.65 to 1.29, p=0.60) favoring aspirin. The estimated hazard ratio for the Catalano study was 0.18 (CI, 0.04 to 0.82, p=0.03) favoring aspirin.

Figure 4Forest plot for RCTs of aspirin versus placebo: nonfatal MI at 2 or more years

Abbreviations: CI=confidence interval; IC=intermittent claudication; PAD=peripheral artery disease.

From: Results

Cover of Treatment Strategies for Patients With Peripheral Artery Disease
Treatment Strategies for Patients With Peripheral Artery Disease [Internet].
Comparative Effectiveness Reviews, No. 118.
Jones WS, Schmit KM, Vemulapalli S, et al.

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