Figure 3 depicts the results of a meta-analysis for the comparison of RFA with PEI/PAI. Three trials reported on the outcome of 3 year overall survival. A random effects model using inverse variance weighting was used. Risk differences are reported for individual trials and for the overall pooled effect. In the first trial, Brunello, 2008, there were 41 events in the RFA group and 39 in the PEI/PAI group. The risk difference was 0.02 favoring RFA with a 95 percent confidence interval of -0.14 to 0.18. The weight of this trial was 30.7 percent. In the second trial, Lin, 2004 there were 38 events in the RFA group and 55 in the PEI/PAI group. The risk difference was 0.21 favoring RFA with a 95 percent confidence interval of -0.05 to 0.36. The weight of this trial was 33 percent. In the third trial, Lin, 2005, there were 46 events in the RFA group and 65 events in the PEI/PAI group. The mean difference was 0.22 favoring RFA with a 95 percent confidence interval of 0.08 to 0.36. The weight of this trial was 36.3 percent. The figure shows a forest plot of these results. The x-axis spans minus 1 at the left favoring PEI/PAI to positive 1 at the right favoring RFA. There is a vertical line at zero that that extends up from the x-axis. The risk difference for each trial is represented by a blue box sized according to the weight of the trial. The confidence interval is represented by a horizontal black line centered on the box. The overall pooled result is represented by a black diamond, the ends of which represent the confidence interval for the pooled result. The blue boxes for all trials and the black diamond fall to the right of the vertical line. Tests for heterogeneity are Tau squared of 0.01, chi squared of 3.88 with 2 degrees of freedom and a p-value of 0.14, and I squared of fourty-eight percent. The Z test for overall effect was 2.48 with a p-value equal to 0.01.

Figure 3RFA compared with PEI/PAI: meta-analysis of three trials for the outcome of overall survival

Abbreviations: -C = Conventional; -HD = High-dose; CI: Confidence interval; IV = Independent variable; PAI = Percutaneous acetic acid injection; PEI = Percutaneous ethanol injection; RFA = Radiofrequency ablation.

From: Results

Cover of Local Therapies for Unresectable Primary Hepatocellular Carcinoma
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