Table 5Third round of SAR study on synthesized analogues

Image ml333fu16.jpg
#CIDRK1 phage IC50 (μM)St. Dev.nCTX. IC50 (μM)St. Dev.nSelectivity (CTX./K1)T7 phage IC50 (μM)St. Dev.n
SID
118337213
Image ml333fu33.jpg
>1003ND*ND*>50
134419006
224248752
Image ml333fu34.jpg
>1003ND*ND*>50
134419026
356643014
Image ml333fu35.jpg
>1003ND*ND*>50
134419005
4601670
Image ml333fu36.jpg
ND*ND*ND*>100
136964061
*

ND = not determined

From: N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits E. coli UT189 bacterial capsule biogenesis

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