Table A10SAR of the Phenyl Group Substituted Hydroxy- and Aminopyridines

SAR AnalysisStructureTarget ActivityAnti-target Activity
Entry No.CID
SID
Broad ID
*
Image ml245fu14.jpg
naHMLE_sh_ECad
EC50 (uM)
nHMLE_sh_Control
EC50 (uM)
Selectivity
R2
14791237
104170322
BRD-K39514895
S
Image ml245fu15.jpg
71.64824.5915.0
Solubility (PBS): 2.6 μMPurity 91%
251351616
121269757
BRD-K05411689
S
Image ml245fu241.jpg
321.873Inactive21.87 vs. inactive
Solubility (PBS): 11.3 μMPurity: >95%
351351636
121269746
BRD-K54708098
S
Image ml245fu242.jpg
317.873inactive17.87 vs. inactive
Solubility (PBS): <1 μMPurity >95%
451351638
121269742
BRD-K53999057
S
Image ml245fu243.jpg
333.23Inactive33.2 vs. inactive
Solubility (PBS): 4.9 μMPurity: 86%
550944062
115950037
BRD-K22613736
S
Image ml245fu244.jpg
342.633Inactive42.63 vs. inactive
Solubility (PBS): NDPurity: >95%

ND = not determined;

*

S = synthesized

S = synthesized

From: Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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