Table 2Solubility for ML282 in Assay Media

Assay Conditions
Dose Response-EDTA buffer: 30mM HEPES, pH 7.5, 100mM KCl, 20mM NaCl, 0.01% (v/v) NP-40, 1mM EDTADose Response-Mg buffer: 30mM HEPES, pH 7.5, 100mM KCl, 20mM NaCl, 0.01% (v/v) NP-40, 1mM MgCl2LDV-FITC assay buffer: RPMI 1640 + 10% HI-FBS)EGFR degradation assay medium: DMEM/F-12, Invitrogen # 11320-082)
ML282
Solubility μg/mL
69.768.1> 116> 116
ML282
Solubility μM
178.5174.4297.1297.1

From: A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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