Figure 1. Some known inhibitors of fungal mitochondria oxidative phosphorylation.

Figure 1Some known inhibitors of fungal mitochondria oxidative phosphorylation

Ilicicolin H (1) has demonstrated 100-fold selectivity for fungal mitochondria in biochemical assays, but displays moderate toxicity against HeLa cells. Antimycin (2) and funiculosin (3) are potent, but non-selective, inhibitors of mitochondrial function.

From: Probing Metabolic Requirements for Fungal Virulence — Probe 1

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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