Table 2Calculated Property Comparison with MDDR Compounds

PropertyML297MDDR Phase IMDDR Launched
MW328.32438.98415.20
cLogP4.073.212.21
TPSA56.7397.0691.78
Hdon2.002.122.13
Hacc5.007.066.47
LogS−4.62−4.96−3.73
NrotB5.307.085.71

From: Discovery and Characterization of a Selective Activator of the G-Protein Activated Inward-Rectifying Potassium (GIRK) Channel

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