Table G-1Correlation table for KQ 2 (management of PAH)

StudyAge (Variability)TimingIndex TestsComparatorsNResultp-value
Andreassen, 20061NR for total cohortBaselineBNPCardiac index61−0.58<0.001
BNPFunctional class610.270.047
BNPRHC-mPAP610.47<0.001
BNPRHC-PVR610.66<0.001
BNPRHC-PVR170.550.041
BNPRHC-sPAP61−0.290.028
BNPRight atrial pressure610.47<0.001
Bendayan, 20022Mean 54.9 (Range 16 to 80)BaselineUric acid6MWD (absolute)29−0.350.03
Uric acidFunctional class290.660.001
Uric acidMortality290.660.001
Uric acidRHC-CO290.060.72
Uric acidRHC-mPAP290.190.17
Bernus, 20093Median 9.3 (Range 5.2 to 14.2)BaselineBNPCardiac index52−0.08NS
BNPPeak TRV470.23NS
BNPPCWP560.26<0.05
BNPRHC-mPAP570.16NS
BNPRHC-PVR560.06NS
BNPRight atrial pressure560.34p<0.05
BNPRV size420.23NS
Borges, 20064Mean 56.4 (SD 11)BaselineRIMP/MPI/Tei Index6MWD (absolute)37−0.730.661
RIMP/MPI/Tei IndexRHC-PVR370.1720.47
TAPSE6MWD (absolute)370.360.028
TAPSERHC-PVR37−0.0720.53
Campana, 20045Mean 50 (SD 11)BaselineBNPCardiac index22r2=0.2 (negative correlation)
BNPRHC-mPAP22r2=0.1
BNPRight atrial pressure22r2=0.09
BNPRVEF22r2=0.46 (negative correlation)
BNPTAPSE22r2=0.005
Cella, 20096Mean 53.8 (SD 13.1)1 yearChange in RVSP6MWD (change)18R2=0.53550.0006
Chin, 20077NRBaselineBNP6MWD (absolute)27−0.590.04
BNPPCWP270.320.10
BNPRHC-CO27−0.250.19
BNPRHC-mPAP270.290.14
BNPRHC-PVR270.280.15
BNPRight atrial pressure270.66<0.001
Dyer, 20068Mean 9.6 (SD 4.8)BaselineRIMP/MPI/Tei IndexRHC-mPAP120.94<0.001
IntermediateRIMP/MPI/Tei IndexRHC-mPAP120.90<0.001
Fahmy Elnoamany, 20079Mean 55.3 (SD 10.39)BaselineEndothelin-1RHC-sPAP530.94<0.001
sPAPRHC-sPAP530.92<0.001
Fijalkowska, 200610Mean 41 (SD 15.1)BaselineBNP6MWD (absolute)55−0.60<0.001
BNPCardiac index55−0.65<0.001
BNPFunctional class550.45<0.001
BNPPeak TRV550.08NS
BNPRHC-mPAP550.21NS
BNPRHC-PVR550.43<0.001
BNPRight atrial pressure550.45<0.001
Forfia, 200611Mean 55 (SD 15)BaselineTAPSERHC-PVR63−0.52<0.0001
Friedberg, 200612NRBaselinemPAPRHC-mPAP170.85<0.0001
mPAPRHC-mPAP170.85<0.0001
sPAPRHC-sPAP170.88<0.0001
sPAPRHC-sPAP170.88<0.0001
Gan, 200613Mean 48 (Range 21 to 80)BaselineBNP6MWD (absolute)30−0.510.008
BNPCardiac index30−0.450.019
BNPRHC-mPAP300.280.143
BNPRHC-PVR300.300.122
BNPRight atrial pressure300.490.008
Ghofrani, 200214Mean 48.3 (SEM 3.7)BaselineANPRHC-PVR200.66<0.0001
cGMPRHC-PVR360.139NS
Goto, 201015Mean 64.07 (SD 12.28)BaselineBNPRHC-mPAP460.5080.044
sPAPRHC-sPAP460.505<0.01
Grubstein, 200816Mean 52 (Range 20 to 80)BaselinesPAPRHC-sPAP380.60.001
Haddad, 200917Mean 49 (SD 11)BaselinemPAPRHC-mPAP510.940.90–0.97
sPAPRHC-sPAP480.970.94–0.98
Heresi, 201018Mean 44 (SD 14)BaselineBNP6MWD (absolute)40−0.58<0.001
BNPCardiac index40−0.310.07
BNPRHC-mPAP400.260.10
BNPRHC-PVR400.150.36
BNPRight atrial pressure400.490.001
Heresi, 201219Mean 47 (SD 13)BaselinecTnI (detectable)6MWD (absolute)68−0.290.020
Functional class680.360.002
BNP680.450.001
RA size680.360.010
Hinderliter, 199720NR for total cohortBaselineFAC6MWD (absolute)750.08
FACCardiac index75−0.01
FACRHC-mPAP75−0.37<0.01
FACRight atrial pressure75−0.01
Pericardial effusion6MWD (absolute)75−0.50<0.01
Pericardial effusionCardiac index75−0.40<0.001
Pericardial effusionRHC-mPAP750.22
Pericardial effusionRight atrial pressure750.50<0.001
RV size6MWD (absolute)75−0.24<0.05
RV sizeCardiac index75−0.16
RV sizeRHC-mPAP750.25
RV sizeRight atrial pressure750.45<0.001
sPAPRHC-sPAP750.57<0.001
Homma, 200121Mean 45.0 (SD 10.6)BaselinesPAPRHC-sPAP8r2=0.11
Leuchte, 200522Mean 46.93 (SEM 2.8)Mean followup 12.6 ± 1.5 monthsChange in BNPChange in 6MWD30−0.74<0.001
Change in BNPChange in cardiac index30−0.49<0.01
Change in BNPChange in RHC-CO30−0.48<0.01
Change in BNPChange in RHC-mPAP300.54<0.01
Change in BNPChange in RHC-PVR300.55<0.01
Change in BNPChange in right atrial pressure300.78<0.001
Machado, 200623NR for total cohortBaselineBNP6MWD (absolute)34−0.540.001
BNPPCWP370.300.07
BNPRA size2110.210.002
BNPRHC-CO37−0.430.006
BNPRHC-dPAP370.370.02
BNPRHC-mPAP370.430.006
BNPRHC-PVR370.510.001
BNPRHC-sPAP370.59
Machado, 200424NR for total cohortBaselineNitric oxideRHC-mPAP120.560.054
sPAPRHC-sPAP170.794<0.001
Montani, 200725Mean 43.8 (Range 33.8–56.6)BaselineEndothelin-1Cardiac index33−0.47<0.008
Endothelin-1RHC-PVR330.55<0.05
Endothelin-1Right atrial pressure330.460.01
Morishita, 200926Mean 32.6 (Range 15–49)BaselinePericardial effusionFunctional class70.34<0.05
RA sizeFunctional class70.33NS
Mukerjee, 200327Mean 57 (Range 34–80)BaselineBNPRHC-mPAP23r2=0.28<0.05
BNPRHC-PVR23r2=0.24<0.05
Nagaya, 200028NR for total cohortBaselineANPPCWP600.22NS
ANPRHC-CO60−0.49<0.001
ANPRHC-mPAP600.42<0.001
ANPRight atrial pressure600.55<0.001
BaselineBNPPCWP600.16
BNPRHC-CO60−0.51<0.001
BNPRHC-mPAP600.42
BNPRHC-mPAP600.43<0.05
BNPRHC-PVR600.59<0.001
BNPRight atrial pressure600.55<0.001
Nath, 200529Mean 46 (SD 11)Long-term >1 yearPeak TRVFunctional class200.260.29
Peak TRVFunctional class200.230.33
Peak TRVFunctional class200.380.10
Nickel, 200830Mean 47.6 (SD 15.8)BaselineBNP6MWD (absolute)139−0.2170.028
BNPCardiac index139−0.3780.001
BNPPCWP139−0.0270.9
BNPRHC-PVR1390.3210.006
BNPRight atrial pressure1390.2830.008
Pyxaras, 201131Mean 55 (SD 19)BaselinesPAPRHC-sPAP600.4570.002
mPAPRHC-mPAP600.4510.006
Souza, 200732Mean 37 (SEM 2)BaselineBNP6MWD (absolute)42−0.310.052
BNPCardiac index42−0.70<0.001
BNPFunctional class420.81<0.001
BNPRHC-mPAP420.58<0.001
BNPRHC-PVR420.80<0.001
BNPRight atrial pressure420.680.004
Takatsuki, 201233Median 10 (Range 5–15)BaselineBNP6MWD (absolute)41−0.320.04
BNPRHC-mPAP470.340.02
BNPRight atrial pressure450.48<0.01
BNPRHC-PVRi460.300.04
BNPRHC-CI41−0.220.16
BNPTRJv690.36<0.01
BNPWHO FC360.320.06
NT-proBNP6MWD (absolute)41−0.49<0.01
NT-proBNPRHC-mPAP470.280.06
NT-proBNPRight atrial pressure450.48<0.01
NT-proBNPRHC-PVRi460.230.12
NT-proBNPRHC-CI41−0.010.93
NT-proBNPTRJv690.41<0.01
NT-proBNPWHO FC360.350.04
Utsunomiya, 200934Mean 46 (SD 13)BaselineRA sizeRight atrial pressure500.310.03
Van Albada, 200835Median 7.0 (Range 0.1–17.3)BaselineBNP6MWD (absolute)29−0.527<0.001
Long-term >1 yearBNP6MWD (change)20−0.630.04
BaselineBNPFunctional class290.340.04
Long-term >1 yearBNPFunctional class200.720.02
Long-term >1 yearBNPMortality299.930.002
BaselineUric acidCardiac index16−0.650.007
Long-term >1 yearUric acidMortality295.930.015
BaselineUric acidRHC-mPAP160.630.01
BaselineUric acidRHC-PVR160.710.03
Vizza, 201236Mean 53 (SD 17)BaselineET-1WHO FC440.350.02
BNP440.510.001
RHC-mPAP440.380.01
RHC-CI44−0.430.004
RHC-PVR440.480.001
Voelkel, 200037NR for total cohortBaselineUric acidRHC-mPAP1910.41<0.0001
Uric acidRight atrial pressure1910.486<0.0001
Williams, 200638Mean 60 (SD 11)BaselineBNPCardiac index68−0.5<0.0001
BNPRHC-mPAP680.62<0.0001
BNPRHC-PVR680.81<0.0001
BNPRight atrial pressure680.53<0.0001
Zafrir, 200739Mean 51 (SD 14.7)BaselineRA size6MWD (absolute)29−0.420.02
Functional class290.390.04
RIMP/MPI/Tei Index6MWD (absolute)29−0.250.18
RVEFFunctional class29−0.450.019

Abbreviations: 6MWD=6-minute walk distance; ANP=A-type natriuretic peptide; BNP=B-type natriuretic peptide ; CO=cardiac output; CVD=collagen vascular disease; FAC=fractional area change; mPAP=mean pulmonary artery pressure; MPI=myocardial performance index; NR=not reported; PCWP=pulmonary capillary wedge pressure; PVR=pulmonary vascular resistance; RA=right atrium; RIMP=right index of myocardial performance; RV=right ventricle; RVEF=right ventricular ejection fraction; SD=standard deviation; SEM=standard error of the mean; sPAP=systolic pulmonary artery pressure; TAPSE=tricuspid annular plane systolic excursion; TRV=tricuspid regurgitant jet velocity

From: Appendix G, Correlation Table for KQ 2

Cover of Pulmonary Arterial Hypertension: Screening, Management, and Treatment
Pulmonary Arterial Hypertension: Screening, Management, and Treatment [Internet].
Comparative Effectiveness Reviews, No. 117.
McCrory DC, Coeytaux RR, Schmit KM, et al.

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