Table A-3PubMed search terms for KQ 3: Monotherapy vs. Combination Therapy for PAH

Set #Terms
#1(“Hypertension, Pulmonary”[Mesh] OR “Idiopathic pulmonary hypertension “[Supplementary Concept]) OR (“pulmonary hypertension”[ti] OR “pulmonary arterial hypertension”[ti] OR “pulmonary artery hypertension”[ti]) OR ((“hypertension, pulmonary”[MeSH Terms] OR “pulmonary hypertension”[tiab] OR (“pulmonary”[tiab] AND “hypertension”[tiab])) AND (pah[ti] OR ipah[ti] OR pph[ti]))
#2(“Calcium Channel Blockers”[Mesh] OR “Calcium Channel Blockers”[Pharmacological Action] OR calcium channel blockers[tiab] OR calcium channel blocker[tiab] OR nifedipine[tiab] OR diltiazem[tiab] OR amlodipine[tiab]) OR (“prostaglandins”[MeSH Terms] OR “prostaglandins”[tiab] OR “prostaglandins”[tiab] OR “prostanoid”[tiab] OR “prostanoids”[tiab] OR “epoprostenol”[MeSH Terms] OR “epoprostenol”[tiab] OR “prostacyclin”[tiab] OR “treprostinil”[Supplementary Concept] OR “treprostinil”[tiab] OR “iloprost”[MeSH Terms] OR “iloprost”[tiab] OR “Receptors, Endothelin/antagonists and inhibitors”[Mesh] OR ((“endothelins”[MeSH Terms] OR “endothelins”[tiab] OR “endothelin”[tiab]) AND (antagonist[tiab] OR “antagonists”[tiab] OR “inhibitors”[tiab])) OR “bosentan”[Supplementary Concept] OR “bosentan”[tiab] OR “ambrisentan”[Supplementary Concept] OR “ambrisentan”[tiab] OR “phosphodiesterase inhibitors”[MeSH Terms] OR (“phosphodiesterase”[tiab] AND “inhibitors”[tiab]) OR “phosphodiesterase inhibitors”[tiab] OR “phosphodiesterase inhibitors”[Pharmacological Action] OR “phosphodiesterase 5 inhibitors”[tiab] OR “phosphoric diester hydrolases”[MeSH Terms] OR (“phosphoric”[tiab] AND “diester”[tiab] AND “hydrolases”[tiab]) OR ((“phosphodiesterase”[tiab] OR “phosphodiesterases”[tiab]) AND (inhibitor[tiab] OR “antagonists and inhibitors”[Subheading] OR “antagonists”[tiab] OR “inhibitors”[tiab] OR antagonist[tiab])) OR (pde5[tiab] AND (inhibitor[tiab] OR “antagonists and inhibitors”[Subheading] OR “antagonists”[tiab] OR “antagonist”[tiab] OR “inhibitors”[tiab] OR “inhibitors”[tiab])) OR pde5i[tiab] OR “sildenafil”[Supplementary Concept] OR “sildenafil”[tiab] OR “tadalafil”[Supplementary Concept] OR “tadalafil”[tiab] OR “Vasodilator Agents”[Mesh:noexp] OR “Vasodilator Agents “[Pharmacological Action])
#3(randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR randomised[tiab] OR randomization[tiab] OR randomisation[tiab] OR placebo[tiab] OR “drug therapy”[Subheading] OR randomly[tiab] OR trial[tiab] OR groups[tiab] OR Clinical trial[pt] OR “clinical trial”[tw] OR “clinical trials”[tw] OR “evaluation studies”[Publication Type] OR “evaluation studies as topic”[MeSH Terms] OR “evaluation study”[tw] OR evaluation studies[tw] OR “intervention studies”[MeSH Terms] OR “intervention study”[tw] OR “intervention studies”[tw] OR “case-control studies”[MeSH Terms] OR “case-control”[tw] OR “cohort studies”[MeSH Terms] OR cohort[tw] OR “longitudinal studies”[MeSH Terms] OR “longitudinal”[tw] OR longitudinally[tw] OR “prospective”[tw] OR prospectively[tw] OR “retrospective studies”[MeSH Terms] OR “retrospective”[tw] OR “follow up”[tw] OR “comparative study”[Publication Type] OR “comparative study”[tw] OR systematic[subset] OR “meta-analysis”[Publication Type] OR “meta-analysis as topic”[MeSH Terms] OR “meta-analysis”[tw] OR “meta-analyses”[tw]) NOT (Editorial[ptyp] OR Letter[ptyp] OR Case Reports[ptyp] OR Comment[ptyp]) NOT (“animals”[MeSH Terms] NOT “humans”[MeSH Terms])
#4#1 AND #2 AND #3 English, Publication Date from 1995 to 2011

From: Appendix A, Exact Search Strings

Cover of Pulmonary Arterial Hypertension: Screening, Management, and Treatment
Pulmonary Arterial Hypertension: Screening, Management, and Treatment [Internet].
Comparative Effectiveness Reviews, No. 117.
McCrory DC, Coeytaux RR, Schmit KM, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.