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Table G-7Exposure-based therapy compared with cognitive restructuring

Domains Pertaining to Strength of EvidenceMagnitude of EffectStrength of Evidence
Number of Studies; Number of SubjectsRisk of Bias; DesignConsistencyDirectnessPrecisionSummary Effect Size (95% CI)High, Moderate, Low, Insufficient
PTSD Symptom Reduction: CAPS
2; 100Medium; RCTsConsistent (I2=0%)DirectImpreciseWMD 4.8 (−4.5 to 14.2)Insufficient
Remission (no longer having symptoms)
0; 0NANANANANAInsufficient
Loss of Diagnosis
2; 100Medium; RCTsConsistent (I2=0%)DirectImpreciseRD 0.13 (−0.06 to 0.32)Insufficient
Prevention/reduction of comorbid depression: BDI
2; 100Medium; RCTsConsistent (I2=0%)DirectImpreciseWMD 2.75 (−1.94 to 7.43)Insufficient
Prevention/reduction of comorbid anxiety
1; 72Medium; RCTNA, single studyDirectImpreciseNo significant differenceInsufficient
Quality of Life
0; 0NANANANANAInsufficient
Disability/functional impairment
0; 0NANANANANAInsufficient
Return to work or return to active duty: % of subjects actively working at 6 month follow up
1; 72Medium; RCTNA, single studyDirectImprecise44% vs. 37%Insufficient

Abbreviations: CI = confidence interval; NA = not applicable; RCT = randomized controlled trial

From: Appendix G, Strength of Evidence

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) [Internet].
Comparative Effectiveness Reviews, No. 92.
Jonas DE, Cusack K, Forneris CA, et al.

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