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Figure F-109 is titled “Change in TOPS/TOP-8 for SSRIs compared with placebo.” The figure displays a forest plot reporting the weighted mean difference in TOPS/TOP-8 scores stratified by fluoxetine compared with placebo and paroxetine compared with placebo. This figure is described further in the “PTSD symptom reduction” section as follows: “Using the TOP-8 as a measure of PTSD symptoms, one trial found greater improvement with fluoxetine compared with placebo (weighted mean difference −2.3; 95% CI, −3.5 to −1.1, N=301); our meta-analysis of trials comparing paroxetine with placebo found greater improvement with paroxetine (weighted mean differences −3.3; 95% CI −4.2 to −2.4; I2=0%, 2 trials contributing 3 comparisons, N=886).”

Figure F-109Change in TOPS/TOP-8 for SSRIs compared with placebo

Timing of outcome assessment: 12 weeks for all included studies.

From: Appendix F, Meta-Analysis

Cover of Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) [Internet].
Comparative Effectiveness Reviews, No. 92.
Jonas DE, Cusack K, Forneris CA, et al.

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