CID/MLTargetIC50 (μM) [SID, AID]Anti-targetIC50 (μM) [SID, AID]Fold SelectiveSecondary Assays (600 nm/405 nm) AbsAC-35 (μM)a and d [SID, AID]
CID 56604881/ML318PvdQ pyoverdine synthesisIC50 = 0.006b [SID 134356610, AID 623951, AID 623985, AID 623991 and AID 623993]24-hour HeLa cell cytotoxicityIC50 = >100c [SID 134356610, AID 623950, AID 623990 and AID 623987]>3200×
  1. wild type (PAO)
  2. wild type (PAK)
    AbsAC-35 = 66.9/12.6 [SID 134356610, AID624073, AID624075]
  3. pump mutant (PAK)
    bsAC-35 = 16.2/1.4 [SID 134356610, AID 624072, AID 624074]
a

AbsAc-35 represents a normalized activity where compounds are compared at a common threshold (-35) (see section 3.1.1).

b

Average of n=4,

c

Average of n=3,

d

Average of n=2.

AbsAc-35 represents a normalized activity where compounds are compared at a common threshold (-35) (see section 3.1.1).

Average of n=4,

Average of n=3,

Average of n=2.

From: Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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