Scheme 2. Synthesis of probe molecule and analogs.

Scheme 2Synthesis of probe molecule and analogs

(i) TFA, 60–100 °C 3–16 h; (ii) method A; R3R4NH (4), 60–80 °C DMA or THF; method B: R3R4NH (4), Me3Al.

From: Identification of Potent and Selective RORĪ³ Antagonists

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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