Table 1Cruzain inhibition of representative analogs

Image ml217fu4.jpg
EntryCIDSIDNCGC IDsIC50 (μM)
41775696229216479NCGC00164730>57
5662541110422459NCGC002414896.4
64985311610422460NCGC00241503>57
74985325310422449NCGC00238716>57
84985328010422451NCGC0023872716
94985322910422449NCGC00238715>57
104985317610422459NCGC002414958.1

Note: all compounds in table were synthesized at NCGC. IC50 values represent the average of three separate experiments.

From: Reversible and non-covalent benzimidazole-based in vivo lead for Chagas disease

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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