Figure 1 is a forest plot of studies reporting the relative risk ratio for short-term mortality with the use of intensive insulin therapy (IIT) by inpatient setting and condition. The figure illustrates the authors' point that, “Over the last decade, IIT trials have failed to replicate these results consistently. Our recent meta-analysis of 21 randomized controlled trials (RCTs), including a total of 14,768 inpatients, found no effect of IIT on short-term mortality (RR 1.00, 95% CI 0.94 to 1.07)…with remarkably little heterogeneity among studies (I2 = 0.0%, p=0.463). The body of evidence is strongest in ICU settings.” This figure is taken, with permission, from the 2011 article by Kansagara and colleagues published in Annals of Internal Medicine.

Figure 1, Chapter 22Short-term mortality in studies of intensive insulin therapy, by inpatient setting and condition

Figure taken from Kansagara et al., 201112

Kansagara D, Fu R, Freeman M, Wolf F, Helfand M. Intensive insulin therapy in hospitalized patients: a systematic review. Ann Intern Med. Feb 15 2011; 154. Permission granted from the American College of Physicians (Annals of Internal Medicine is the original source of the material).

From: Chapter 22, Inpatient Intensive Glucose Control Strategies To Reduce Death and Infection (NEW)

Cover of Making Health Care Safer II
Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices.
Evidence Reports/Technology Assessments, No. 211.

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