Table G9Hydrocortisone compared with placebo

Outcome: Number of Studies, Number of Subjects; DesignRisk of BiasConsistencyDirectnessPrecisionMagnitude of Effect: Summary Effect Size (95% CI)Strength of Evidence
Incidence of PTSD: 1; 28; RCTMediumaUnknown, single studyDirectImprecisebHydrocortisone vs. placebo, PTSS-10, 7.1% vs. 21.4%, p=NRInsufficient
PTSD symptom severity at 6 monthsa: 1; 28; RCTMediumaUnknown, single studyDirectImprecisebHydrocortisone vs. placebo, PTSS-10 median rank, 15.5 vs. 25.5, p=0.03Insufficient
Incidence and severity of psychological symptoms at 6 months: 1; 28; RCTMediumaUnknown, single studyDirectImprecisebHydrocortisone vs. placebo, Unnamed structured and validated questionnaire, no significant difference between groups in number and type of traumatic memories, p≤0.33Insufficient
Incidence/severity of comorbid conditions: 0; 0NANANANANAInsufficient
Quality of Life at 6 months: 1; 28; RCTMediumaUnknown, single studyDirectImprecisebHydrocortisone vs. placebo, SF-36 physical function, 85 vs. 38, p=0.01; Pain, 25 vs. 0, p=0.01; general health perception, 72 vs. 60, p<0.01; vitality, 58 vs. 40, p<0.01; mental health, 80 vs. 64, p=0.01Insufficient
Return to work/return to active duty or ability to work: 0; 0NANANANANAInsufficient
Incidence of self-injurious or suicidal thoughts, attempts, or behaviors (including suicide): 0; 0NANANANANAInsufficient
Incidence of aggressive or homicidal thoughts, attempts, or behaviors (including homicide) 0; 0NANANANANAInsufficient
a

Groups different at baseline on some measures; high (> 20%) overall attrition

b

Small sample size (< 300 observations)

Abbreviations: CI = confidence interval; NA = not applicable; NR = not reported; PTSD = posttraumatic stress disorder; PTSS-10 = Posttraumatic Stress Symptom 10 Question Inventory; RCT = randomized controlled trial; SF-36 = Medical Outcomes Study Health Survey – Short Form-36

Groups different at baseline on some measures; high (> 20%) overall attrition

Small sample size (< 300 observations)

From: Appendix G, Psychological, Pharmacological, and Emerging Interventions: Strength-of-Evidence Grades

Cover of Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma
Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma [Internet].
Comparative Effectiveness Reviews, No. 109.
Gartlehner G, Forneris CA, Brownley KA, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.