Table G22Strength of evidence for subgroup effects of gender

Outcome: Number of Studies; Number of Subjects; DesignRisk of Bias; Design/QualityConsistencyDirectnessPrecisionMagnitude of Effect: Summary Effect Size (95% CI)Strength of Evidence
Incidence of PTSD: 0; 0NANANANANAInsufficient
PTSD symptom severity: 2; 268; RCTMediumaConsistentbDirectNot reportedcNot reporteddLowe
Depression symptom severity: 1; 157; RCTMediumaUnknownfDirectNot reportedcNot reporteddInsufficientg
Quality of Life: 0; 0NANANANANAInsufficient
Return to work/return to active duty or ability to work: 0; 0NANANANANAInsufficient
Incidence of self-injurious or suicidal thoughts, attempts, or behaviors (including suicide): 0; 0NANANANANAInsufficient
Incidence of aggressive or homicidal thoughts, attempts, or behaviors (including homicide): 0; 0NANANANANAInsufficient
Perceived utility: 0; 0NANANANANAInsufficient
a

Unmasked RCT

b

Upgraded for consistency

c

Downgraded for unclear precision

d

Downgraded for unclear magnitude of effect

e

Low SOE because magnitude and precision of effect not reported by either of the two studies.

f

Downgraded as a single study

g

Insufficient because findings reported by only one medium risk of bias trial and magnitude, direction and precision not reported.

Abbreviations: CI = confidence interval; NA = not applicable; PTSD = posttraumatic stress disorder; RCT = randomized controlled trial; SOE = strength of evidence

Unmasked RCT

Upgraded for consistency

Downgraded for unclear precision

Downgraded for unclear magnitude of effect

Low SOE because magnitude and precision of effect not reported by either of the two studies.

Downgraded as a single study

Insufficient because findings reported by only one medium risk of bias trial and magnitude, direction and precision not reported.

From: Appendix G, Psychological, Pharmacological, and Emerging Interventions: Strength-of-Evidence Grades

Cover of Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma
Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma [Internet].
Comparative Effectiveness Reviews, No. 109.
Gartlehner G, Forneris CA, Brownley KA, et al.

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