Figure A: This figure depicts the analytic framework for the comparative effectiveness of psychological, pharmacological, and emerging interventions to prevent posttraumatic stress disorder (PTSD) in adults following exposure to psychological trauma. The Key Questions are displayed within the context of the population, intervention, comparator, outcome, timing, and setting described in the previous section. Beginning with a population of adults exposed to psychological trauma, the figure illustrates the efficacy and comparative effects of early preventive interventions on incidence of PTSD or health outcomes, including incidence and severity of trauma-related symptoms, incidence and severity of comorbid conditions, quality of life, quality of interpersonal or social functioning, ability to return to work or duty, incidence of self-injurious or suicidal thoughts, attempts, or behaviors including suicide, incidence of aggressive or homicidal thoughts, attempts, or behaviors including homicide, perceived utility of intervention, and resilience (Key Question 1). Timing, intensity, and dosage of intervention as potential moderators of these interventions are explored in Key Question 2. Characteristics of traumatic exposure and subgroups within the overall population identified based on age, sex, race and ethnicity, psychiatric comorbidities, and personal risk factors of PTSD as potential moderators of these interventions are explored in Key Question 3. Finally, Key Question 4 addresses the absolute and comparative risks of harms and adverse events from these interventions.

Figure AAnalytic framework for comparative effectiveness of interventions to prevent PTSD in adults after exposure to trauma

KQ = Key Question; PTSD = posttraumatic stress disorder

From: Executive Summary

Cover of Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma
Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma [Internet].
Comparative Effectiveness Reviews, No. 109.
Gartlehner G, Forneris CA, Brownley KA, et al.

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