Table 33Oxybutynin (pre vs post treatment) - Clinical study characteristics and clinical summary of findings

No. of studiesDesignTreatment (n)Control (n)ResultsLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Outcome: Continence
1 [A]ObservationalOxybutynin (41)-No. incontinent Before vs after 35/41 vs 11/35
RR 2.72 (1.64 to 4.50)
S (i)NNNNVery low
1 [B]Prospective open label trialOxybutynin (111)-% catheterisation without intermittent leaking accident Increase from baseline 21.5%; p<0.001S (i)NNN (iI)NVery low
1 [C]ObservationalOxybutynin (37)-Before vs after Regularly dry 1/37 vs 18/37
Always wet between micturations 18/37 vs 3/37
S (i)NNNNVery low
1 [D]ObservationalOxybutynin (35)-Virtually dry between catheterisations 25/35
Significant wetting 8/35
S (i)NNN (ii)NVery low
1 [E]ObservationalOxybutynin (13)-Mostly continent 5/13 Significant improvement 3/13 No improvement 5/13S (i)NNN (ii)NVery low
1 [F]ObservationalOxybutynin (30)-Of the 29 incontinent 3 achieved continence and 19 decreased use of padsS (i)NNN (ii)NVery low
Outcome Maximum cystometric capacity
1 [A]ObservationalOxybutynin (41)-Before vs after mean (SD) mL 141 (96) vs 197 (99); p<0.01 MD 56S (i)NNN (ii)NVery low
1 [G]ObservationalOxybutynin Oral (67)Intravesical (34)Before vs after mean (SD) mL oral 128 (107) vs 214 (110) MD 86
−49.26) Intravesical 132 (103) vs 226 (118) MD 94
S (i)NNN (ii)NVery low
1 [B]Prospective open label trialOxybutynin (111)-Before vs after mean (SD) mL 196.9 (122.3)) vs 260.5 (126.111.97) ; p<0.001 MD 63.6S (i)NNN (ii)NVery low
1 [E]ObservationalOxybutynin (13)-Increased capacity 10/13 mean increase 41% (range −24 to + 95%)S (i)NNN (ii)NVery low
1 [F]ObservationalOxybutynin (30)-Before vs after mean (SD) mL 209 (103) vs 282 (148); p<0.01 MD 73S (i)NNN (ii)NVery low
Outcome: Bladder compliance
1 [A]ObservationalOxybutynin (41)-Before vs after mean (SD) mL/cmH20 6.5 (5.6) vs 16.8 (13.7); p<0.01 MD 10.3S (i)NNN (iI)NVery low
1 [G]ObservationalOxybutynin Oral (67)Intravesical (34)Before vs after mean (SD) mL/cmH20 Oral 8.1 (6.3) vs 14.8 (11.6) MD 6.7 Intravesical 8.5 (6.1) vs 16.0 (11.0) MD 7.5S (i)NNN (iI)NVery low
1 [E]ObservationalOxybutynin (13)-Improved compliance 12/13S (i)NNN (ii)NVery low
Outcome: Adverse events (side effects)
1 [A]ObservationalOxybutynin (41)-13/41S (i)NNN (ii)NVery low
1 [C]ObservationalOxybutynin (39)-2/39S (i)NNN (ii)NVery low
1 [D]ObservationalOxybutynin (35)-2/35S (i)NNN (ii)NVery low
1 [F]ObservationalOxybutynin (30)-0/30S (i)NNN (ii)NVery low
Outcome: Urinary tract infections (UTI)
1 [G]ObservationalOxybutynin Oral (67)Intravesical (34)Experienced a decrease 70/101S (i)NNN (ii)NVery low
1 [C]ObservationalOxybutynin (33)-Before vs after Asymptomatic bacteriuria 10/33 vs 14/33 Lower UTI 11/33 vs 21/33 Upper UTI 9/33 vs 8/33 Use of prophylactic antibiotics 15/33 vs 15/33S (i)NNN (ii)NVery low
1 [D]ObservationalOxybutynin (35)Observation (13)Treament vs observation Gp UTI 2/35 vs 0/13 asymptomatic bacteriuria 21/35 vs 0/13NNNN (ii)NVery low
Outcome: Treatment adherence (Discontinuations)
1 [G]ObservationalOxybutynin Oral (67)Intravesical (34)Oral 11/67 Intravesical 6/34S (i)NNN (ii)NVery low
1 [C]ObservationalOxybutynin (39)-7/39S (i)NNN(ii)NVery low
1 [D]ObservationalOxybutynin (35)-2/35S (i)NNN (ii)NVery low
1 [E]ObservationalOxybutynin (28)-15/28S (i)NNN (ii)NVery low
1 [H]ObservationalOxybutynin (23)-15/23S (i)NNN (ii)NVery low

S serious N none RR relative risk MD mean difference CI confidence interval


Before vs after data


Imprecision could not be assessed, data at high risk of bias


Goessl et al. (1998)53


Franco et al. (2005)52


Amark et al. (1998)61


Baskin et al. (1990)49


Connor et al. (1994)50


Painter et al. (1996)57


Ferrara et al. (2001)51


Palmer et al. (1997)58

From: 8, Treatment to improve bladder storage

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
National Clinical Guideline Centre (UK).
Copyright © 2012, National Clinical Guideline Centre.

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