Table I.7.14GRADE findings for comparison of vaginal misoprostol with placebo for the management of incomplete miscarriage

Quality assessmentNumber of women or averageEffectQuality
Number of studiesDesignLimitationsInconsistencyIndirectnessImprecisionDetails of treatment regimen (dose in micrograms unless stated)MisoprostolPlaceboRelative (95% CI)Absolute (95% CI) and P value (if stated)
Success of medical treatment
1 study

(Bagratee et al., 2004)
randomised trialno serious limitationsno serious inconsistencyno serious indirectnessvery serious1,2600 vaginal misoprostol (Ms)

(repeat after 24h)
7/7

(100%)
12/14

(85.7%)
RR 1.12

(0.84 to 1.5)
103 more per 1000

(from 137 fewer to 429 more)
Low
Need for further intervention
1 study

(Blohm et al., 2005)
randomised trialno serious limitationsno serious inconsistencyno serious indirectnessvery serious1,2400 vaginal Ms0/7

(0%)
2/11

(18.2%)
RR 0.3

(0.02 to 5.46)
127 fewer per 1000

(from 178 fewer to 811 more)
Low
1 study

(Bagratee et al., 2004)
randomised trialno serious limitationsno serious inconsistencyno serious indirectnessvery serious1,2600 vaginal Ms

(repeat after 24h)
0/7

(0%)
2/14

(14.3%)
RR 0.38

(0.02 to 6.9)
89 fewer per 1000

(from 140 fewer to 843 more)
Low

CI confidence interval, Ms misoprostol, P probability, RR relative risk

1

Small sample size (N ≤ 50)

2

Wide confidence intervals

From: Appendix I, GRADE tables

Cover of Ectopic Pregnancy and Miscarriage
Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage.
NICE Clinical Guidelines, No. 154.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG; 2012 Dec.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK [www.cla.co.uk]. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.