Table I.7.7GRADE findings for comparison of mifepristone with placebo for the management of missed miscarriage

Quality assessmentNumber of womenEffectQuality
Number of studiesDesignLimitationsInconsistencyIndirectnessImprecisionDetails of treatment regimenMifepristone (Mf)PlaceboRelative (95% CI)Absolute (95% CI) and P value (if stated)
Success of medical treatment
1 study

(Lelaidier et al., 1993)
randomised trialserious1no serious inconsistencyno serious indirectnessserious2600 mg oral Mf19/23

(82.6%)
2/23

(8.7%)
RR 9.5

(2.49 to 36.19)
739 more per 1000

(from 130 more to 1000 more)
Low
Need for further intervention
1 study

(Lelaidier et al., 1993)
randomised trialserious1no serious inconsistencyno serious indirectnessserious2600 mg oral Mf6/23

(26.1%)
19/21

(90.5%)
RR 0.29

(0.14 to 0.58)
642 fewer per 1000

(from 380 fewer to 778 fewer)
Low
Adverse effects: incidence of endometritis
1 study

(Lelaidier et al., 1993)
randomised trialserious1no serious inconsistencyno serious indirectnessserious2,3600 mg oral Mf1/23

(4.3%)
1/21

(4.8%)
RR 0.91

(0.06 to 13.69)
4 fewer per 1000

(from 45 fewer to 604 more)
Low
Pain: incidence
1 study

(Lelaidier et al., 1993)
randomised trialserious1no serious inconsistencyno serious indirectnessserious2,3600 mg oral Mf12/23

(52.2%)
5/21

(23.8%)
RR 2.19

(0.93 to 5.17)
283 more per 1000

(from 17 fewer to 993 more)
Low

CI confidence interval, Mf mifepristone, P probability, RR relative risk

1

No baseline characteristics illustrating comparability of the two arms are reported

2

Small sample size (N ≤ 50)

3

Wide confidence intervals

No baseline characteristics illustrating comparability of the two arms are reported

Small sample size (N ≤ 50)

Wide confidence intervals

From: Appendix I, GRADE tables

Cover of Ectopic Pregnancy and Miscarriage
Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage.
NICE Clinical Guidelines, No. 154.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG; 2012 Dec.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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