Box 4Summary of considerations related to the strength of the recommendations (Recommendations 16-20)

Recommendation1617181920
InterventionTranexamic acid for PPH treatmentUterine massage for PPH treatmentIntrauterine balloon tamponade for PPH treatmentUterine artery embolization for PPH treatmentSurgical interventions for PPH treatment
Quality of the evidence□ High
☒ Moderate
□ Low
□ Very low
□ High
□ Moderate
□ Low
☒ Very low
□ High
□ Moderate
□ Low
☒ Very low
□ High
□ Moderate
□ Low
☒ Very low
□ High
□ Moderate
□ Low
☒ Very low
Values and preferences□ No significant variability
☒ Significant variability
☒ No significant variability
□ Significant variability
□ No significant variability
☒ Significant variability
□ No significant variability
☒ Significant variability
☒ No significant variability
□ Significant variability
Absolute magnitude of effect□ Large effect (RR>2 or RR<0.5)
☒ Small effect (0.5<RR<2)
□ Large effect (RR>2 or RR<0.5)
☒ Small effect (0.5<RR<2)
☒ Large effect (RR>2 or RR<0.5)
□ Small effect (0.5<RR<2)
☒ Large effect (RR>2 or RR<0.5)
□ Small effect (0.5<RR<2)
☒ Large effect (RR>2 or RR<0.5)
□ Small effect (0.5<RR<2)
Balance of benefits versus disadvantages☒ Benefits outweigh disadvantages
□ Benefits and disadvantages are balanced
□ Disadvantages outweigh benefits
☒ Benefits outweigh disadvantages
□ Benefits and disadvantages are balanced
□ Disadvantages outweigh benefits
☒ Benefits outweigh disadvantages
□ Benefits and disadvantages are balanced
□ Disadvantages outweigh benefits
☒ Benefits outweigh disadvantages
□ Benefits and disadvantages are balanced
□ Disadvantages outweigh benefits
☒ Benefits outweigh disadvantages
□ Benefits and disadvantages are balanced
□ Disadvantages outweigh benefits
Resource use□ Less resource intensive
☒ More resource intensive
☒ Less resource intensive
□ More resource intensive
□ Less resource intensive
☒ More resource intensive
□ Less resource intensive
☒ More resource intensive
□ Less resource intensive
☒ More resource intensive
Feasibility□ Yes, globally
☒ Yes, conditionally
☒ Yes, globally
□ Yes, conditionally
□ Yes, globally
☒ Yes, conditionally
□ Yes, globally
☒ Yes, conditionally
□ Yes, globally
☒ Yes, conditionally
Recommendation direction☒ In favour of the intervention
□ Against the intervention
☒ In favour of the intervention
□ Against the intervention
☒ In favour of the intervention
□ Against the intervention
☒ In favour of the intervention
□ Against the intervention
☒ In favour of the intervention
□ Against the intervention
Overall ranking□ Strong recommendation
☒ Weak recommendation
☒ Strong recommendation
□ Weak recommendation
□ Strong recommendation
☒ Weak recommendation
□ Strong recommendation
☒ Weak recommendation
☒ Strong recommendation*
□ Weak recommendation

From: Annex 3, Summary of the considerations related to the strength of the recommendations (Balance Worksheets)

Cover of WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage
WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage.
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