Table 2: Extraction Solvents

Extraction SolventSolvent StrengthPolarityBPDielectric Constant% of Solvent in Water% of Water in Solvent
Heptane0.010981.920.00030.01
Toluene0.292.41102.40.670.046
MTBE0.472.55544.81.5
Diethyl ether0.382.8354.36.891.3
Methylene Chloride0.423.1409.081.60.17
Chloroform0.44.1614.810.8150.072
Ethyl Acetate0.584.4776.028.79.8
Butanol0.73.911717.87.820.1

From: HPLC-MS/MS for Hit Generation

Cover of Assay Guidance Manual
Assay Guidance Manual [Internet].
Sittampalam GS, Coussens NP, Nelson H, et al., editors.
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