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This set of figures use the example of a review entitled “The effectiveness of disease-modifying anti-rheumatic drugs (DMARDS) in children with juvenile idiopathic arthritis (JIA)” to illustrate how treatment of JIA in children with DMARDs versus intra-articular corticosteroids and NSAIDs may result in intermediate outcomes (e.g., changes in laboratory measures of inflammation, changes in the active joint count, or radiologically evident progression of disease) and/or long-term outcomes (e.g., clinical remission, changes in quality of life, changes in growth, and changes in development). In addition, adverse events may occur at any point after the treatment is received. The examples of select aspects of topic refinement are shown in 3 sections: Nomination, changes to elements of the nominated topic, and the example analytic framework illustrating the integration of the key questions into the topic. The Nomination section figure depicts the key questions within the context of the PICOTS described the methods section.

Appendix Figure B1Nomination: The effectiveness of disease-modifying anti-rheumatic drugs in children with juvenile idiopathic arthritis

Note: DMARD= disease-modifying anti-rheumatic drug, JIA=juvenile idiopathic arthritis, KQ=key question, NSAID=nonsteroidal anti-inflammatory drug, PICO=population, intervention, comparator, outcome.

From: Appendix B, Example of Selected Aspects of a Topic Refinement

Cover of The Refinement of Topics for Systematic Reviews
The Refinement of Topics for Systematic Reviews: Lessons and Recommendations From the Effective Health Care Program [Internet].
Buckley DI, Ansari M, Butler M, et al.

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