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Table 6Drugs potentially used for the treatment of ERT infusion-associated reactions

Severity of ReactionAntipyreticAntihistaminicAnti-inflammatorySympathicomimeticH2 Receptor Antagonist
MildAcetaminophen IbuprofenChlorpheniramine HydroxyzineNANANA
ModerateAcetaminophen IbuprofenChlorpheniramine (IV)Hydrocortisone (IV)NANA
Severe (anaphylaxis)Acetaminophen IbuprofenChlorpheniramine (IV)Hydrocortisone (IV)Epinephrine (IM)
Albuterol (nebulized)
Ranitidine (IV)

IM = intramuscular; IV = intravenous; NA = not applicable

From: Findings

Cover of Enzyme-Replacement Therapies for Lysosomal Storage Diseases
Enzyme-Replacement Therapies for Lysosomal Storage Diseases [Internet].
Technical Briefs, No. 12.
Ratko TA, Marbella A, Godfrey S, et al.

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