Table 4.9Quality Assessment for studies reporting progression free survival

No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Progression Free Survival
1randomised trialsserious1no serious inconsistencyno serious indirectnessserious2noneLow
1

The intervention under investigation meant that the study was subject to lead time bias, though steps were taken to address this.

2

The number of events did not accumulate at the expected rate resulting in an under-powered study.

The intervention under investigation meant that the study was subject to lead time bias, though steps were taken to address this.

The number of events did not accumulate at the expected rate resulting in an under-powered study.

From: 4, Management of Metastatic Disease

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Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer.
NICE Clinical Guidelines, No. 131.
National Collaborating Centre for Cancer (UK).
Copyright © 2011, National Collaborating Centre for Cancer.

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