Table 4.8Quality Assessment for studies reporting overall survival

No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Overall Survival
6observational studiesserious1no serious inconsistencyserious2no serious imprecisionnoneVery Low
1Observational studyvery serious3no serious inconsistencyno serious indirectnessno serious imprecisionnoneVery Low
1

Studies included in the systematic review were retrospective studies and consisted of both comparative and non-comparative studies

2

with some studies describing only the results of initial chemotherapy included in the systematic review, no information on treatment sequence was provided by these studies.

3

This was a small (n=35) retrospective case series study with very little information provided in the publication as it was an update of an initial series.

From: 4, Management of Metastatic Disease

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Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer.
NICE Clinical Guidelines, No. 131.
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Copyright © 2011, National Collaborating Centre for Cancer.

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