Table 6.34Evidence profile for pharmacokinetic outcomes of 1 million units of intravenous benzylpenicillin given to healthy women in the third trimester of pregnancy

Number of studiesNumber of womenEffectQuality
Intravenous benzylpenicillin groupComparison groupRelative (95% confidence interval)Absolute (95% confidence interval)
Serum concentration at 4 hours
1
(Johnson 2001)
a-NCNCVery low
Mean maximum serum concentration (microgram/ml)
1
(Johnson 2001)
b-NCNCVery low
Mean area under the curve (hour × mg/ml)
1
(Johnson 2001)
c-NCNCVery low
Mean total clearance (l/hour/kg)
1
(Johnson 2001)
d-NCNCVery low
Mean volume of distribution in the steady state (l/kg)
1
(Johnson 2001)
e-NCNCVery low
Half-life (hours)
1
(Johnson 2001)
f-NCNCVery low
Average serum penicillin concentration after 4 hours of urine collection (microgram/ml)
1
(Johnson 2001)
g-NCNCVery low

NC not calculable, SD standard deviation

a

Serum concentration was above the minimum inhibitory concentration at 4 hours of urine collection

b

Dichotomous data not reported: (n=15) Mean maximum serum concentration ± SD (range) = 67.8 ± 25.7 (33.8 to 131.8) microgram/ml

c

Dichotomous data not reported: (n=15) Mean area under the curve ± SD (range) = 34.4 ± 18.7 (18.1 to 92.6) hour × mg/ml

d

Dichotomous data not reported: (n=15) Mean total clearance ± SD (range) = 0.25 ± 0.07 (0.13 to 0.43) l/hour/kg

e

Dichotomous data not reported: (n=15) Mean volume of distribution in the steady state ± SD (range) = 0.27 ± 0.19 (0.11 to 0.82) l/kg

f

Dichotomous data not reported: (n=15) Half-life ± SD (range) = 0.2 ± 0.09 (0.1 to 0.4) hours

g

Dichotomous data not reported: (n=15) Average serum penicillin concentration 12 microgram/ml (range 9 to 25) after 4 hours of urine collection

See the complete GRADE Table J 6.34

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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