Table 6.22Evidence profile for ampicillin-sulbactam and indomethacin compared with placebo in women with preterm labour

Number of studiesNumber of babies/womenEffectQuality
Ampicillin- sulbactam and indomethacinPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Neonatal sepsis
1
(Newton 1991)
1/45
(2.2%)
1/47
(2.1%)
RR 1.04 (0.07 to 16.20)*1 more per 1000 (from 20 fewer to 323 more)*Low
Necrotising enterocolitis
1
(Newton 1991)
1/45
(2.2%)
1/47
(2.1%)
RR 1.04 (0.07 to 16.20)*1 more per 1000 (from 20 fewer to 323 more)*Low
Perinatal mortality
1
(Newton 1991)
0/45
(0%)
2/47
(2.1%)
RR 0.21 (0.01 to 4.23)*34 fewer per 1000 (from 42 fewer to 137 more)*Low
Gestational age at birth (weeks)
1
(Newton 1991)
4042-MD 1.00 higher (0.71 lower to 2.71 higher)Low

RR relative risk

*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.22

Calculated by the NCC-WCH technical team from data reported in the article

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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