Table 5.9Evidence profile for diagnostic test accuracy of prematurity and low birthweight for predicting early-onset neonatal infection

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Prematurity or low birthweight
Gestational age < 26 weeks (babies born at gestational age < 28 weeks or birthweight < 1000 g; prediction of infection in the first 7 days of life)
1(Ronnestad 2005)46236.7
(19.4 to 53.9)
67.4
(62.9 to 71.8)
1.12
(0.69 to 1.83)
0.94
(0.71 to 1.24)
Moderate
Gestational age < 28 weeks (for prediction of culture-proven infection in the first 7 days of life)
1 (Yancey 1996)8236.67
(0.17 to 32.0)*
99.6
(99.2 to 100.0)*
18.0
(1.98 to 162.8)*
0.94
(0.82 to 1.07)*
Moderate
Gestational age < 28 weeks (for prediction of clinical infectionc in the first 7 days of life)
1 (Yancey 1996)8230.86
(0.02 to 4.71)*
99.6
(99.1 to 100.0)*
2.02
(0.21 to 19.2)*
0.996
(0.991 to 1.000)*
Moderate
Gestational age < 37 weeks (for prediction of culture-proven infection in the first 7 days of life)
1 (Yancey 1996)82353.3
(28.1 to 78.6)*
83.5
(81.0 to 86.1)*
3.24
(1.97 to 5.33)*
0.56
(0.33 to 0.96)*
Low
Gestational age < 37 weeks (for prediction of clinical infectiona in the first 7 days of life)
1 (Yancey 1996)82329.9
(21.6 to 38.2)*
85.0
(82.4 to 87.6)
1.99
(1.44 to 2.77)
0.83
(0.73 to 0.93)
Moderate
Prematurity (not defined) in babies with suspected infection in the first 48 hours of life
1 (Blot 1983)7220.7
(5.95 to 35.4)*
90.7
(82.0 to 99.4)*
2.22
(0.69 to 7.20)*
0.87
(0.71 to 1.08)
Moderate
Prematurity in babies born after prolonged rupture of membranes (>18 hours)
For prediction of culture-proven infection in the first 7 days of life
1 (Yancey 1996)11661.5
(35.1 to 88.0)*
39.6
(25.8 to 53.4)*
1.02
(0.63 to 1.66)*
0.97
(0.45 to 2.11)*
Low
For prediction of clinical infectionc in the first 7 days of life
1 (Yancey 1996)11641.9
(27.1 to 56.6)*
67.7
(56.5 to 78.8)*
1.29
(0.79 to 2.12)*
0.86
(0.64 to 1.16)*
Moderate
Prematurity in babies born to women with previous miscarriage
Gestational age < 32 weeks (prediction of probable infectionb in the first 7 days of life)
1 (Martius 1999)34338
(NC)
82
(NC)
2.11*
(NC)
0.76*
(NC)
Low
Gestational age < 35 weeks (prediction of probable infectionb in the first 7 days of life)
1 (Martius 1999)34337
(NC)
81
(NC)
1.95*
(NC)
0.78*
(NC)
Low

NC not calculable

*

Calculated by the NCC-WCH technical team from data reported in the article

a

Clinical infection defined as culture-proven or suspected infection

b

Probable infection based on clinical and laboratory findings

See the complete GRADE Table J 5.9

Calculated by the NCC-WCH technical team from data reported in the article

Clinical infection defined as culture-proven or suspected infection

Probable infection based on clinical and laboratory findings

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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